In silico and in vitro antimicrobial testing of ethanol extract of Xylopia aethiopica against Salmonella typhimurium and Shigella species isolated from Wistar rats infected with Trypanosoma evansi and Trypanosoma brucei brucei

Plants with antimicrobial potential have been implicated in the treatment of infection. Studies shown that extracts from diverse plants antibacterial and or antitrypanosomal activities against infectious agents. This research work examined vitro testing ethanol extract Xylopia aethiopica Salmonella typhimurium Shigella species isolated wistar mouse already infected Trypanosoma evansi brucei brucei, 60 16 weeks old were used was randomly grouped into 8 groups where N = 5 group A, B, E, F,G H. N=15, C D. A: control, B uninfected but treated (346.4mg/kg/bwt XAEE. Group untreated (T. Brucei brucei), D evansi). E 346.4 mg/kg/bwt XAEE). F. When molecular docking simulation used, lots phytochemicals identified screened XAEE project work. Findings an indication fruits Shigella.